15 Aug Stem Cell Therapy for Kidney Failure
As Type-2 diabetes and high blood pressure continue to plague the world, the demand for kidney transplants is increasing by the day. Owing to a shortage of organ donors to meet this requirement, stem cell therapies emerge as a hope to cure thousands of patients as an alternative treatment.
How does a Kidney Failure occur?
Our kidneys are designed to prevent toxins build up in our bodies. Kidneys help remove a lot of waste, cleansing our bodies from within so that no harmful toxins and chemicals destroy our vital organs. Our kidneys also produce hormones to control other body functions.
When more than a third of your kidney function is impaired, chronic kidney disease begins to take place. Other diseases such as diabetes also contribute to worsening this condition. When left untreated, chronic kidney disease gradually worsens and may result in kidney failure in some cases.
When this happens, patients have to rely on a kidney transplant and dialysis to stay alive and perform day to day activities.
Do Stem Cells help in Kidney Failure?
Stem cells possess the unique capacity to self-renew if they are provided the right environment. Therefore, stem cells are used to replace or repair damaged tissues. This is why stem cells can be of significant help in treating kidney failure.
There has been a lot of research to study the effects of stem cells to regenerate a damaged kidney and re-establish its lost function. The past few decades have shown a substantial improvement in identifying how stem cells can play their role in treating several medical conditions such as kidney failure.
How does it work?
Researchers have concentrated on focusing on how human induced pluripotent stem cells and bone marrow mesenchymal stem cells (MSCs) can deliver maximum results in restoring kidney function.
Mesenchymal stem cells regenerate into several different types of stem cells. These cells can be incorporated into the renal tubular cells and develop into mesangial cells. Moreover, these cells revitalize the kidney’s stem cells and support the survival of renal cells by discharging growth stimulants, to initiate the natural recovery process.
How successful is the Treatment?
Cases in which stem cells are taken from bone marrow and fat to treat patients suffering from chronic nephritis (resulting in kidney failure) have revealed positive outcomes.
The treatment involves delivering the mesenchymal stem cells and the bone marrow directly into the kidneys to begin repairing the damage on their own.
In the same way, stem cell therapy is also useful in treating complicated conditions such as multiple myeloma, (which also leads to a kidney failure), by transplanting bone marrow stem cells.
Although we are yet to declare the stem cell therapy to be the ultimate treatment for kidney failure, it is definitely useful in slowing down and sometimes suspending the progression of CKD.
Modern stem cells therapies that are currently available utilize stem cells to repair and regenerate damaged renal cells and improve the function of the kidney to slow down the disease’s progression.