How do stem cells help the body heal?

How do stem cells help the body heal?

While a great amount of research has been carried out on stem cells and their potential, there is yet a lot to learn!

Here is some important information about the treatment of knee osteoarthritis with autologous adipose-derived stem cells or ADSCs.

Research has showed that stem cells do not have a single mechanism of action. While stem cells have the unique ability to differentiate into a different tissue types and act as regenerative cells, there are several potential mechanisms of action. All of these mechanisms help in increased healing and comfort for the patient and include –

Anti-Inflammatory

Many diseases involve inflammation that gives rise to chronic pain. Studies show that stem cells restrict inflammatory responses and promote anti-inflammatory pathways. When injected in an inflammatory environment, stem cells may change cytokine secretion to alter the environment from pro-inflammatory to anti-inflammatory. Hence, stem cells show an immunomodulatory ability that can balance the person’s immune system.

Trophic Support

Stem cells secrete cytokines and growth factors which support the development of new blood vessels, also known as angiogenesis. Stem cells aid tissue remodeling, differentiation, and antiapoptotic events. In other words, they offer trophic support that includes cellular growth, differentiation, and survival. All these aspects are essential to healing.

Homing

Stem cells have a unique ability to home or move to areas of injury or inflammation. They have shown to move from the injection site to a distant site where they may be needed for healing injured tissues.

While the multiple modes of stem cells’ action may not be completely understood yet, research shows that patients who undergo autologous adipose-derived stem cell therapy for orthopedic conditions experience a reduction in pain, improved mobility, and an improved quality of life.

 

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