12 Nov Lipoaspirate – SVF & Prolotherapy
Adipose tissue is an immensely valuable reservoir for stem cell banking and therapy. It can be easily harvested by liposuction as the lipoaspirate.
Until recently, it used to be discarded as a waste material from the liposuction procedures, but now it can be processed by enzymatic or mechanical techniques to obtain a stem cell-rich stromal vascular fraction (SVF). SVF contains various kinds of stem cells, such as multipotent stromal cells called adipose-derived mesenchymal stromal cells (ASC), endothelial cells (EC), endothelial progenitor cells (EPC), pericytes, preadipocytes, and hematopoietic cells. These have potent angiogenic properties, which can be utilized for curative therapies for a variety of diseases.
Many clinical trials have demonstrated safety and efficacy of autologous SVF as used in regenerative cell therapy for a variety of diseases.
SVF from lipoaspirate has shown significant potential for soft tissue repair and reconstruction in plastic surgery. It has been used for postmastectomy breast reconstruction, cosmetic breast augmentation, facial restructuring, scar and deformity correction, etc.
Unlike the human bone marrow stromal/stem cells that are present in small amounts in the bone marrow, ASCs can be retrieved in high number from lipoaspirate or subcutaneous adipose tissue fragments. Adipose stem cells are similar to bone marrow stromal/stem cells and share the ability to grow bone or cartilage.
Whole joint Lipoaspirate Prolotherapy is another novel therapeutic approach involving the lipoaspirate. It involves drawing lipoaspirates from the abdomen through a quick liposuction procedure.
Lipoaspirate Prolotherapy is used in more severe cases of joint deterioration. Lipoaspirates are the preferred source of stem cells for prolotherapy because it is densely packed with stem cells. These lipoaspirates are combined with platelet-rich plasma (PRP) drawn from blood. This primary proliferant solution is then injected into the damaged, painful joint. The ligament and tendon attachments of the joint are also treated with dextrose Prolotherapy.
Lipoaspirate Prolotherapy is generally used in more severe cases, where a very strong proliferant can speed the healing process faster than dextrose prolotherapy.
Combining lipoaspirate stem cells with Platelet Rich Plasma Therapy to accelerate tissue regeneration in advanced degeneration has attempted and studies are underway to prove its efficacy. PRP increase the stem cells’ ability to cause tissue healing. In some ways, PRP assists stem cells in helping them differentiate into specific cell types. Early research has shown that platelets enhances MSC stem cell proliferation as well as differentiation. The platelets do so by secreting a variety of chemicals, such as cytokines, adhesive proteins, and growth factors.
Lipoaspirate prolotherapies could be needed for a full year or longer. It is best suited for patients who have one of the suitable indications and refuses or has failed surgery. While this approach is novel and still experimental, there is a great promise and the evidence is beginning up to back it up. Consult with your doctor and discuss if any of these therapies are permitted, available and suitable for you.