Stem Cell Knee Cartilage Clinical Trials

Stem Cell Knee Cartilage Clinical Trials

Stem cells can be found throughout the body and act as repairmen to stimulate healing and speed repair of injured tissues. Although cell-based injections are promising, there is still a need to determine the efficiency and safety of such treatments.

With cartilage and bone damage, stem cells could potentially differentiate and produce bone, cartilage, and tissues, and has the potential to heal damaged tissues within the body. Stem cells are cells with the power to multiply and renew.


Types of cells with this ability include:

  • Mesenchymal stem cells (MSC)
  • Umbilical stem cells
  • Fetal stem cells
  • Adipose tissue
  • Amniotic
  • Molar cells

They work by activating the body’s natural healing process using the body’s own healthy cells to stimulate regeneration and natural healing.

MSC’s are found primarily in bone marrow and can self-replicate, decrease inflammation, and differentiate into cartilage, bone, muscle, and fat cells to help the body regenerate injured tissues.

The treatment helps with the regeneration of cartilage but if there is significant bone damage does not repair the joint itself. However, after knee surgery, stem cell therapy helped reduce pain and enhanced repair.

MSC cells can differentiate to a variety of cell types including:

  • Bone cells (osteoblasts)
  • Cartilage cells
  • Muscle cells
  • Fat cells

The MSC cells have been used to treat multiple joint and musculoskeletal problems with a goal to reduce inflammation and promote regeneration. MSC’s do not survive very long but last long enough to generate anti-inflammation and tissue regeneration signals.

Clinical trials also focus on osteoarthritis which affects the elderly population causing swelling, pain, instability, decreased range of motion and functional disability. Although promising, there are many regulatory requirements.

The use of stem cells in the treatment of cartilage injury and osteoarthritis is increased in clinical and animal studies. Delivery systems vary from injection to implantation of stem cells. While highly promising, there is still little evidence of clinical benefit requiring further research to assess the overall outcomes for knee cartilage repair.

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