03 Feb Understanding Stromal Vascular Fraction
Generally, when people talk about “fat stem cell treatment,” they refer to “stromal vascular fraction.” Fortunately, stromal vascular fraction or SVF has gained a lot of traction in recent years. The cell concentration process can help people enhance neovascularization and angiogenesis in wound healing. It is also an effective way to improve healing in cardiovascular and urogenital diseases.
However, if you have never heard about stromal vascular fraction or SVF, its application in the medical processes may overwhelm you.
Continue reading to understand the SVF, its process, application, and benefits.
Stromal Vascular Fraction- An Overview
Stromal vascular fraction typically is a cellular extraction made in a lab from fat.
While the method or process to make the SVF extract may vary, the primary idea involves separating cells. That means experts separate a variety of body cells in the fat tissues from gloppy fat tissues. The experts then concentrate these cells to produce SVF.
The extraction method uses an enzyme called collagenase and requires a unique molecular sledgehammer. The enzymes in the process chew up all the fat tissues’ proteins to connect with different cells. The enzymes are harsh and need careful handling.
These enzymes need to release the cells to produce SVF. Cells are sparsely present within tissues and hard to find. The SVF’s end product is not a naturally occurring substance. While most of the Stromal vascular fraction cells exist in the fat that experts use to extract them, they are not together.
Moreover, cell exposure to the enzyme often changes their inherent nature and behavior in some ways. The stress of the method may generate a new kind of cells with many novel properties. In principle, experts can produce Stromal vascular fraction from almost all tissues to isolate vascular and stromal cells.
Cells Used in SVF
As mentioned above, experts can produce SVF using different cells. The exact type and number of cells vary from individual to individual. Some cells generally are suitable for Stromal vascular fraction preparations. Fibroblasts, for instance, make a good number of stromal cells. Fat cells and adipocytes with some fat cell progenitors are also present in the process.
Benefits of Stromal Vascular Fraction
A large number of clinical studies have examined the benefits and safety of stromal vascular fraction. The researchers have tested the methods in a variety of contexts, mainly wound healing, urogenital, cardiovascular, respiratory diseases, and musculoskeletal conditions. Clinical trials have shown beneficial results of SVF used as treatment or therapy.
According to experts, SVF may provide a molecular and cellular microenvironment to regulate ASC activities in various clinical conditions. SVF may also enhance vascularization in urogenital, wound healing, and cardiovascular diseases.
Moreover, its therapeutic benefits for different joint conditions rely on its anti-inflammatory mechanism and paracrine immune-modulatory. Several novel care methods have emerged to improve SVF and to meet the medical requirement.
All in all, stromal vascular fraction is a popular treatment that uses laboratory-generated stem cells.