Using Stem Cell Therapy to Manage Crohn’s Disease

Using Stem Cell Therapy to Manage Crohn’s Disease

Stem cell therapy has emerged as a fascinating and very promising treatment for a wide variety of different conditions. Stem cells have proven to be useful for helping to fight certain problems that are typically quite difficult to treat medically. One condition that is being studied for stem cell treatment is Crohn’s disease.

How Could Stem Cells Help With Crohn’s Disease?

Researchers currently don’t know the cause of Crohn’s disease, which makes it difficult to treat. Both genetic and environmental factors are believed to contribute to the condition.

While researchers aren’t certain about the cause, it is speculated that the disease is caused by chronic inflammation. This occurs when T-cells are activated, damaging tissue in the digestive tract.

 

Researchers also believe that genes related to our immunity may be related to Crohn’s.

Knowing this, researchers have begun to use stem cells to help manage Crohn’s disease. There are a number of ways in which stem cells might help with Crohn’s disease.

Treatment often involves the use of mesenchymal stem cells (MSCs). These stem cells are known to be highly effective at helping to reduce and eliminate inflammation. These particular stem cells are useful for helping to improve a wide variety of inflammatory conditions.

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Because T-cell activation causes inflammation in the gut, researchers began to experiment using MSCs to help reduce inflammation in people with Crohn’s disease. MSCs are able to enter the body and adopt the role of damaged or inflamed tissues, helping to reduce chronic illness and repair degenerating tissue.

One study evaluated the use of MSCs taken from bone marrow. The study found that patients saw an improvement that lasted for at least four years.

The quality of life was evaluated, as were physical symptoms. Patients showed an improvement in Fistula tracts, an irregular connection between different body parts which often causes pain and discomfort. 75% of the people treated with stem cells had their fistulas completely close after 4 years.

 

Another study evaluated the use of MSCs for fighting irritable bowel disease (IBD), an umbrella term under which Crohn’s disease falls.

MSCs help activates M2 macrophages. These are known as wound-healing macrophages which help to reduce inflammation and instigate the body’s healing responses. This means that MSCs can encourage the body to heal.

People who were treated using this method of therapy had a fair success rate, with 53% of patients having a remission in their condition. 47% of these patients experienced an endoscopic improvement 42 days after the stem cells were implanted into their body.

Stem cell therapy has been used to help treat a variety of conditions, including Crohn’s disease. Stem cells, especially mesenchymal stem cells, have the unique ability to encourage the body to activate its own healing mechanisms and reduce inflammation.

Studies from stem cell therapy Chicago that followed patients treated with MSCs showed that many experienced an improvement in their condition after being given their treatment. This shows that stem cell therapy has a lot of promise for treating Crohn’s and other inflammatory bowel diseases.

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