Adipose SVF Stem Cell Therapy for Neurological Conditions
Adipose-derived stem cells are acquired from the patient’s own body (autologous). CSN utilizes an IRB approved protocol that yields 10 million – 40 million stem cells.
These stem cells are being used in many therapies for neurological conditions, such as multiple sclerosis and Parkinson’s disease. Stromal vascular fraction (SVF) of adipose (fat) tissue is a rich source of mesenchymal stem cells (MSCs).
What is SVF?
Stromal vascular fraction is a component of lipoaspirate, which is fat cells obtained from liposuction of excess adipose tissue. Lipoaspirate contains stem cells, which have the capacity for multilineage differentiation. SVFs are being used for many neurological conditions.
What is involved in the stem cell therapy outpatient procedure?
Stem cell therapy takes around 4 hours. During the procedure, expect:
Harvest – The doctor may administer twilight or local anesthesia to the patient. After a small incision is made on the body, 100-200 milliliters of adipose tissue are harvested.
Separate – With advanced protocols, the stromal vascular fraction with adult stem cells is separated from the macrophages, fat cells, and other tissue components. This is done in the laboratory using centrifugation.
Isolation – Adult stem cells are isolated from SVF using multi-filtration protocols in the laboratory.
Infusion – The stem cells are administered via infusion or through customized administration measures and possibly injected.
What are the advantages of using adipose stem cells when compared to other sources?
Adipose tissue yields a much higher number of stem cells than blood or bone marrow. In 200 milliliters of adipose tissue, there are millions of dormant stem cells. Bone marrow only yields thousands. In addition, patients receive their own stem cells, so there is low risk for a reaction or adverse immune event. MSCs have been proven to transform into other types of cells, which mean they can become nerve cells to use in the therapy of neurological conditions.
How do stem cells work?
Stem cells are infused or deployed into the bloodstream, and also may be, injected into localized tissues. Stem cells are attracted to signals from inflammatory cells. Distressed signals also trigger stem cells to differentiate into other cells. These differentiation cells will integrate with target tissues, such as nerves, cartilage, bone, etc.
What current neurological conditions use stem cell therapy?
Conditions Using Stem Cell Therapy include:
Multiple sclerosis – This condition involves destruction of the myelin sheath, which surrounds nerves and causes major disability. In clinical studies, stem cells implanted into an injured spinal cord were found to generate new neurons (nerve cells), as well as oligodendryocytes. This led to locomotor and mobility recovery.
Recent studies performed by CSN have shown great promise for SVF-derived stem cells in the therapy of multiple sclerosis. Over the course of two years, multiple sclerosis patients that underwent therapy by CSN showed a 52% reduction in MISS-29 scores. For instance, at the beginning of the study average baseline MISS-29 scores nearly reached 90, with follow up scores 2 years later averaging below 40.
Parkinson’s disease – With this disease, there is gradual loss of nerve cells and degeneration of some other neurons. This causes rigidity, tremor, loss of mobility, and postural instability. Stem cells have been found to offer long-lasting improvement through regeneration of nerve cells. In a study involving rats, the implantation of stem cells into brains resulted in lesion repair.
Like multiple sclerosis, CSN patients that have undergone therapy for Parkinson ’s disease have shown improvement. At present, the CSN success rate for treating Parkinson’s disease is 64.80%.
Stroke – An ischemic stroke results in loss of function of one side of the body. Researchers have transplanted progenitor cells into the brains of mice following a stroke and found they differentiated into glial and neuron cells, which re-established connections with targeted brain regions.
CSN patients that have received autologous stem cells for complications of stroke have experienced a success rate of 55%.
Amyotrophic lateral sclerosis (ALS) – This results in degeneration and dysfunction of motor neurons of the spinal cord, cerebral cortex, and brainstem. Stem cell therapy has been proven to establish functional synapses in rat subjects. When stem cells were delivered into the cerebrospinal fluid of rats with motor neuro injury, the researchers found the cells migrated to the spinal cord and induced motor function recovery through neuroprotective mechanisms.
Complex Regional Pain Syndrome (CRPS)
Reflex Sympathetic Dystrophy (RSD)
Post Concussion Syndrome
Lindvall O & Kokaia Z (2006). Stem cells for the treatment of neurological disorders. Nature, 441(29).